DNA Gridiron Nanostructures Based on Four-Arm Junctions

Authors: Han, D., Pal, S., Yang, Y., Jiang, S., Nangreave, J., Liu, Y., and Yan, H.
Title: DNA Gridiron Nanostructures Based on Four-Arm Junctions
Source: Science
Year: 2013
Volume: 339
Pages: 1412-1415


Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.

Date of online publication: Fri, 2013-03-22
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